Natural Stacks Review: My Honest Opinion


Nootropics supplements have been gaining popularity in recent years. Especially with the increased interest in the brain and biohacking. Since they have become so popular, there are now many brands, but not all are created equal.

Natural Stacks is a nootropics brand that I wanted to try. I tried a few of their products and wanted to share some honest thoughts about how they affected me. But let’s go over the basics of nootropics first.

What Are Nootropics And Why Use Them?

Nootropics (also called ‘smart drugs’ or cognitive enhancers) are substances that affect the brain in one way or another. They can protect the brain or improve cognitive performance. Nootropics can also increase the efficiency of neurotransmitter production and how they act on brain cells.

What is Natural Piles?

Natural Stacks is a quality supplement company focused on better brain health. The idea is to “stack” your supplements so that you have something that is tailored to your needs. Instead of trying to get everything we need in one supplement (which isn’t going to happen).

You can get their pre-packaged stacks for specific health needs, such as mood, brain foods, and mental performance, or make your own bundle of supplements. They offer products individually, but stacking them gives you the best discount. More on that at the end of this review, but now let me tell you how Natural Stacks worked for me.

NEUROFUEL™ by Natural Stacks

NEUROFUEL™ is the original supplement from Natural Stacks. It was originally called CILTEP, an acronym for “Chemically-Induced Long Term Potentiation.” However, don’t let the name fool you! Natural Stacks is made with all-natural ingredients.

The “chemically induced” part refers to how it increases biochemical functions in the brain. Neurofuel does this through a few different actions:

  1. Inhibiting PDE Enzymes
  2. Increase CAMP Levels

#1 Inhibitory Phosphodiesterase (PDE) Enzymes

PDE enzymes would otherwise break down something called cyclic adenosine monophosphate (cAMP). Blocking PDEs has a positive effect on memory. Blocking PDE4 in particular is beneficial for neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. It can also increase alertness and focus. Some natural PDE4 inhibitors include artichoke extract, luteolin, and an herb called Kanna.

#2 Increasing CAMP Levels (Cyclic Adenosine Monophosphate)

cAMP naturally enhances the action of hormones and neurotransmitters. These include epinephrine (adrenaline) and acetylcholine. While blocking PDE helps increase cAMP levels, Neurostack’s ingredients also directly increase them. This is due to the herb Coleus forskohlii with its active ingredient forskolin. Neurofuel uses artichoke extract to help block PDE as well.

By blocking PDE and increasing cAMP, it has a powerful effect on a process known as long-term potentiation. Scientists believe that this process is the key to learning and retaining new information.

Neurofuel also contains an amino acid, acetyl-L-carnitine (ALCAR). This amino acid crosses the blood-brain barrier to aid mitochondria and boost energy. ALCAR also helps fight brain fog and fatigue.

The L-phenylalanine in the formula helps build dopamine for focus and motivation. And the active form of vitamin B6 reduces feelings of stress and helps create calm, focused energy. You can see why Neurofuel is so effective for clarity, focus, memory and motivation!

My Experience with NEUROFUEL™

I got to try both their capsule and their lemonade drink packs. I could feel both products within half an hour. Despite a few short nights of sleep, after taking Neurofuel, I felt focused, clear-headed and ready to be productive. It was a great way to start the day.

I especially liked the lemonade packs because it’s a great way to make sure I start the day with a glass of water on an empty stomach. They mix easily without sinking to the bottom of the glass and taste great!

The flavor comes from crystallized lemon extract, with some stevia and organic monk fruit for sweetness. No funny business here.

SEROTONIN BRAIN FOOD™ from Natural Stacks

Serotonin (also known as the “happy molecule”) is a neurotransmitter that helps us feel calm, focused and optimistic. Scientists have found that 95% of the body’s serotonin is produced in the gut. When we give our body the right nutrients, we can increase serotonin production in the gut.

Natural Stacks’ Serotonin Brain Food has the nutrients needed for optimal serotonin production.

  • Rhodiola Rosea – Supports stress relief, fights fatigue and burnout, improves mood and increases energy and performance.
  • L-tryptophan – An essential amino acid that boosts mood, improves cognitive skills and promotes positive behavior. The gut converts tryptophan into serotonin.
  • Vitamin B3 – Increases blood flow in the brain, helps produce energy and protects the body from free radical damage.
  • Magnesium glycinate – Helps relieve stress, improve attention, improve sleep quality and improve memory.
  • Zinc Glycinate – Supports a healthy immune system and helps increase serotonin in the brain.

Healthy serotonin levels are linked to:

  • Positive social behavior
  • Resilience under stress
  • Optimism
  • Humour
  • Cognitive Flexibility
  • Better mental health in general

My Experience with Natural Stacks Serotonin Brain Food™ Supplement

I usually took the serotonin supplement in the evening, but also during the day on some cloudy days. I could definitely feel an effect; generally a sense of balanced calm and a brighter outlook. I think it helped me sleep a little better when I took it at night.

SMART CAFFEINE® from Natural Stacks

Sometimes you just need a little extra caffeine… but without the jitters. Smart Caffeine from Natural Stacks combines caffeine with the calming amino acid L-theanine for a balanced energy boost. L-theanine is the found balancing amino acid that comes from green tea.

The two work together to improve attention and alertness, memory and cognitive functioning. It even helps us ignore distractions. What mom doesn’t need that!

A 2008 study found that L-theanine and caffeine worked synergistically to improve speed and accuracy when multitasking. The combination also reduced study participants’ susceptibility to distraction during a memory task. Together they help improve performance when we really need to use our brainpower.

My Experience with Natural Stacks Caffeine Supplement

I could definitely feel the caffeine, and it didn’t take long for it to start working. I took it mid-morning when I was sitting at my laptop typing an article, and started to feel a little sleepy. It helped bring my focus back quickly and I felt much more productive for the rest of the day. So far I’ve only taken it when needed.

Natural piles as a whole: my opinion

Overall, I found Natural Stacks supplements to be very effective and quite fast. They are a great nootropics hack to have on hand when I need to focus and be productive. Especially after a night of sub-optimal sleep. The Neurofuel and Smart Caffeine pair well together to get the most out of the day.

The Serotonin Brain Food is also a great addition to have on the shelf for days when you just “don’t feel it”.

I love that their ingredients are all-natural and backed by science. While I’ve tried these three products, they have others that you can add to your stack or experiment with. They have a few other neurotransmitter-enhancing supplements, including:

  • Acetylcholine Brain Food – For more attention to detail, faster thinking and mental clarity.
  • GABA Brain Food – For a calm mind, clear thoughts, a relaxed body and a deeper, more restorative sleep.
  • Dopamine brain food – For laser focus, unbeatable drive to get things done, better athletic balance and better mental clarity.

They also have magnesium, curcumin, krill oil, probiotics and vitamin D3 supplements. There’s even a drink mix to support sleep and gut health all at once. If you’re not sure what to try first, you can order one of their stacks, which combine two to four supplements in one kit.

They even allow you to build your own stack. Just choose a product from each of the three categories: Neurotransmitter Support, Mental Performance and Daily Essentials. Then you automatically receive a 15% discount on the collection.

I look forward to trying more of their products! If you’d like to try Natural Stacks at 15% off, click here to go to their website and enter wellnessmama15 at checkout.

Have you tried nootropics products before? What was your experience with them? Share it with us below!


  1. Hayashi Y. (2022). Molecular mechanism of hippocampal long-term potentiation – Towards multiscale understanding of learning and memory. Neuroscience Research175, 3-15.
  2. Levenson C.W. (2006). Zinc: the new antidepressant?. Nutrition Reviews, 64(1), 39-42.
  3. Lou H.C. (1994). Dopamine precursors and brain function in phenylalanine hydroxylase deficiency. Acta pediatrica (Oslo, Norway: 1992). Supplement407, 86-88.
  4. Owen, GN, Parnell, H., De Bruin, EA, & Rycroft, JA (2008). The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutritional Neuroscience11(4), 193-198.
  5. Richard, DM, Dawes, MA, Mathias, CW, Acheson, A., Hill-Kapturczak, N., & Dougherty, DM (2009). L-tryptophan: fundamental metabolic functions, behavioral research and therapeutic indications. International Journal of Tryptophan Research : IJTR, 2, 45-60.
  6. Sanders, O., & Rajagopal, L. (2020). Phosphodiesterase inhibitors for Alzheimer’s disease: a systematic review of clinical trials and epidemiology with a mechanistic rationale. Journal of Alzheimer’s disease reports4(1), 185-215.
  7. Southwick, S.M., Vythilingam, M., & Charney, D.S. (2005). The psychobiology of depression and resilience to stress: implications for prevention and treatment. Annual Review of Clinical Psychology1, 255-291.
  8. Tang, L., Huang, C., Zhong, J., He, J., Guo, J., Liu, M., Xu, JP, Wang, HT, & Zhou, ZZ (2019). Discovery of arylbenzylamines as PDE4 inhibitors with possible neuroprotective effect. European journal of medicinal chemistry168, 221-231.